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Efficacy and Mechanism Evaluation (EME)

Home Funding Funding opportunities Efficacy and Mechanism Evaluation (EME)

The EME Programme funds ambitious studies evaluating interventions with potential to make a step-change in the promotion of health, treatment of disease, and improvement of rehabilitation or long-term care. Within these studies, the programme supports research in the mechanisms of diseases and treatments.

EME looks to attract studies with novel methodological designs that deliver results more efficiently, reduce the study timeline and maximise the knowledge gained. The translational research it supports covers a wide range of new and repurposed interventions, such as diagnostic or prognostic tests, decision-making tools, therapeutics or psychological treatments, medical devices, and public health initiatives delivered in the NHS.

The programme supports clinical trials and evaluative studies in patients that: evaluate clinical efficacy of interventions where proof-ofconcept in humans has already been achieved, add significantly to our understanding of biological or behavioural mechanisms and processes, or explore new scientific or clinical principles. There are two workstreams: researcher-led and commissioned. Both workstreams fund large projects with clear stages and milestones. Proposals may include pilot and feasibility studies and late development of technologies. The programme welcomes collaborations with industry and charities.

The EME Programme is a partnership between the Medical Research Council (MRC) and the NIHR.

Calls/Competitions Researcher-led and commissioned calls
Application process Typically two-stage
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